About

Erasmus MC is the academic hospital of the city of Rotterdam in the Netherlands and home to the Erasmus University Faculty of Medicine. With 1320 beds it is the second largest hospital in the Netherlands. It has internationally acknowledged expertise in the fields of clinical sciences, health sciences and biomedical sciences and plays a leading role in the field of genomics, epigenomics and bioinformatics.

Expertise

The Department of Epidemiology at Erasmus MC is home to two large prospective cohort studies. The Generation R Study is a prospective cohort study from foetal life until young adulthood in a multi-ethnic urban population. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from foetal life until young adulthood. The children form a prenatally recruited birth cohort that will be followed until young adulthood. In total, 9778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study.

The Rotterdam Study (RS) is an ongoing population-based, prospective cohort study, which started in 1990-1993 in a suburb of the city of Rotterdam the Netherlands, and which includes a total of 14,926 participants of age 45 years and over at baseline, in three subcohorts. The original subcohort (RS-I) enrolled 7983 participants aged 55 years or older in 1990-1993. Two additional sub cohorts (RS-II, with 3011 participants of 55 years and older; and RS-III with 3932 participants of 45 years and older) were recruited into the study in 2000-2001 and 2006-2008, respectively.

Both the Generation R Study and the Rotterdam Study have extensive biobanks and will contribute to the DynaHEALTH project.

Our team

Professor Vincent W.V. Jaddoe

Paediatrician-epidemiologist and DynaHEALTH Lead Investigator

Vincent is a paediatrician-epidemiologist at Erasmus University Medical Centre – Sophia Children’s Hospital. He is also Principal Investigator of the Generation R Study. The general aim of his research line is to explore how genetic and environmental exposures lead to maternal gestational complications, foetal and childhood developmental adaptation mechanisms, and risk factors for common diseases, in particular cardiovascular disease, type 2 diabetes, obesity and respiratory diseases. His research is largely embedded in the Generation R Study. Many of his studies are performed in close collaboration with the Harvard School of Public Health, Boston, USA, in the Early Growth Genetics (EGG) and Early Growth and Longitudinal Epidemiology (EAGLE) Consortia. Vincent is also involved in several EU Framework-7 funded research programmes.

Dr Janine F. Felix, MD, PhD

Epidemiologist, assistant professor focusing on maternal and child health, specifically on the role of genetic and epigenetic factors in cardiometabolic disease and obesity.

Dr M. Arfan Ikram, MD PhD

Head of neuroepidemiology in the Rotterdam Study. He has a longstanding interest in epidemiology of brain ageing and dementia, including Alzheimer’s disease, using state-of-the-art imaging technologies.

Florianne O.L. Vehmeijer, MD

Florianne is a PhD student investigating associations of pregnancy and early life exposures and maternal and child cardio-metabolic outcomes, and their underlying epigenetic mechanisms.

Role in this project

Erasmus MC is Work Package 1 lead and is involved in research tasks in Work Package 3.